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Stuyvesant High School (pronounced /ˈstаɪvɨsənt/), commonly referred to as Stuy (/ˈstаɪ/),[3] is a New York City public high school that specializes in mathematics and science. It is one of the most competitive public high schools in the United States, sending more students to some of the nation's most prestigious universities than most other public or private schools.[5] The school opened in 1904 on Manhattan's East Side and moved to a new building in Battery Park City in 1992. Stuyvesant is noted for its strong academic programs, having produced many notable alumni including four Nobel laureates.[6] U.S. News & World Report ranked it twenty-third in their 2008 list of America's best "Gold-Medal" high schools.[7]

Together with Brooklyn Technical High School and Bronx High School of Science, Stuyvesant is one of the three original academic Specialized High Schools of New York City. Run by the New York City Department of Education, the trio are open to New York City residents and charge no tuition. Admission to each is by competitive examination only, of which Stuyvesant has the highest cutoff score. A long-standing friendly rivalry between Stuyvesant and Bronx Science exists over the Intel Science Talent Search, with each school claiming dominance over the other at various times.

Established as a manual trade school for boys, Stuyvesant became coeducational in 1969. Upon the construction of its Battery Park City building, the facilities for girls became on par with those for boys.